| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
Visible Light-induced 3D Bioprinting Using Photocrosslinkable Biopolymers and Water-soluble Photoinitators |
| 초록 |
Three dimensional (3D)-bioprinting offers an innovative stratergy to fabricate functional tissues and organs with high complexicity and precision. Within this framework, digital light processing (DLP) technique using photocrosslinkable bioinks consisting of photosensitive biopolymers and photoinitiators (PIs) allows to prepare 3D complex hydrogels with tissue-specific properties. However, poor biocompatibility and low photoreactivity of the available bioinks limit their use in the fabrication of cell-laden 3D tissue constructs. Here, we report a fast-curable low-energy bioprinting system using a photosensitive hyaluronic acid (HA) and type I PIs based on benzoyl phosphinate for visible light-induced 3D bioprinting. After examining the water solubility, molar extinction coefficients, photocrosslinking efficiency and biocompatibility of the PIs, curved corneal structure was fabricated and the viability of corneal stroma cells in the 3D-printed constructs were evaluated. Overall, the HA-based photoreactive bioinks exhibited superior properties to function as a fast-curing visible light-induced 3D printing for use in tissue engineering applications. |
| 저자 |
Ajeesh Chandrasekharan1, 이경원2, 김소담2, 이혜선2, 안선영2, 양승윤2
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| 소속 |
1Pusan National Univ., 2부산대 |
| 키워드 |
tissue engineering; 3D bioprinting; hyaluronic acid; water-soluble photoinitator
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| E-Mail |
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