| 초록 |
A conventional microneedle patch has the disadvantages of weak mechanical properties and low drug-release efficiency when using polymers such as hyaluronic acid, chitosan, cellulose, and polycaprolactone. In this study, we prepared a novel microneedle patch using metal bioelectrodes that provide excellent mechanical properties, drug-delivery efficiency, and biocompatibility at the same time. This biocompatible polyvinylpyrrolidone (PVP) based hydrogel-type microneedle patch was prepared using gamma rays. The back side of the PVP based microneedle patch were coated with gold or silver (which provides excellent electrical conductivity) as bioelectrodes. The drug-release efficiency increased more than 7.9 times compared to a flat patch (without applying electricity) when 3 V was applied. |
