| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Poly(dimethysiloxane) based Medical Device Surface Coating with Hyaluronic Acid-Gelatin Crosslinked Hydrogel to Reduce Fibrosis Formation |
| 초록 |
Polydimethylsiloxane (PDMS) has been applied in many fields due to its attractive features such as biocompatibility, low toxicity, ease of fabrication, gas permeability, and low manufacturing costs. However, its surface hydrophobicity limits successful in implementation, and this must be reduced by surface modification. Here, to modify the PDMS surface, Hydrogels were fabricated from hyaluronic acid and gelatin using a Schiff-base reaction. A decrease in the water contact angle confirmed the hydrophilicity of the surface. The modified hydrophilic surface showed antibacterial adhesion, and improved distribution of human adipose-derived stem cells without cell cytotoxicity. Decreased fibrosis tissue responses were observed in vivo with looser collagen distribution and reduced cytokine expression on the hydrogel-coated surface. Hydrogel coating on PDMS is a promising method to improve the surface hydrophilicity and biocompatibility for surface modification of biomedical applications. |
| 저자 |
차낫차몬, 주해진, 박종현, 김한구, 배태휘, 김우섭, 최진화, 김미경, 강신혁, 박한수
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| 소속 |
중앙대 |
| 키워드 |
polydimethylsiloxane; surface coating; hydrogel; Schiff-base reaction; hydrophilicity
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| E-Mail |
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