| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Development and characterization of injectable human keratin based hydrogels |
| 초록 |
Injectable hydrogels have received great attention for tissue engineering because of minimally invasive procedure, easy to handle, capability of encapsulating bioactives. Recently, keratin extracted from human hair has emerged as fascinating biomaterials due to its excellent biocompatibility, biodegradability, low immune reaction and plenty of resource. Despite of these advantages, the low solubility of keratin in aqueous solutions significantly hinders its widespread applications. In this study, in situ-forming keratin based hydrogels were developed. Keratin-poly(ethylene glycol) (PEG)-tyramine (KPT) conjugates were synthesized by grafting tyramine to keratin using a PEG linker. KPT hydrogels were prepared by HRP catalyzed reaction and their physico-chemical properties were characterized. Finally in vitro cell-cytotoxicity test showed great biocompatibility. From these results, we can suggest the in situ forming KPT hydrogels have a great potential for tissue engineering application. |
| 저자 |
박나정1, 이윤기1, 최수지2, 박경민3, 황유식2, 박기동1
|
| 소속 |
1아주대, 2경희대, 3인천대 |
| 키워드 |
Keratin; Hydrogel; Tissue engineering
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| E-Mail |
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