| 초록 |
Natural polyphenols are important nutrients in foods which possesses complementary and alternative medicinal effects. The polyphenols are bulky biomolecules having structures like L-3,4-dihydroxyphenylalanine and the multiple hydroxyl groups are useful for adsorbing proteins. Herein, we have developed a chemical modification process for the preparation of HA-polyphenol derivatives. Four different polyphenols were successfully attached to hyaluronic acid (HA). 1H NMR, and FT-IR confirmed the covalent bonding, whereas UV assay highlighted that the substitution rate increased with polyphenols. The DPPH scavenging assay confirmed the recovered antioxidant activities even after chemical reaction. Adhesion strength of derivatives under the uniaxial tensile strain mode is almost double than that of the neat HA. This improved adhesion and antioxidant behavior of these derivatives may come from the 1,2-dihydroxy structure and multiple phenols. |
