| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.458 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Synthesis and characterization of biodegradable polysuccinimide grafted Gd-DOTA : the micelle-form as a potential contrast agent |
| 초록 | Polysuccinimide (PSI) has physico-chemical characteristics for development of macromolecular prodrugs, due to biocompatibility, biodegradability, easy synthesis, low cost and easy functionalization.1-3 We deal with the synthesis of PSI having various functional groups such as D,L-lysine and Gd-DOTA via ring opening of PSI. And the formation of nanoparticle micelles as drug carrier was also examined. PSI was synthesized by polycondensation polymerization of aspartic acid. Functionalization of PSI was carried out by introduction of D,L-lysine and Gd-DOTA into PSI. Micelle size was measured by ELS and AFM. Also, we were measured NMR, EDS, and EA. Fig. 1 showed NMR spectra. Fig 2 showed analysis of EDS and EA. Fig. 1 NMR spectra of PSI-lysine Fig. 2 EDS and EA analysis of PSI-lysine-DOTA-Gd Acknowledgement : This work was supported by KMOCIE(10011394). 참고문헌 1. T. Ouchi, M. Shiratani, M. Jinno, M. Hirao and Y. Ohya, Macromol. Chem., 14, 825 (1993). 2. T. Hayashi and M. Iwatsuki, Biopolymers, 29, 549 (1990). 3. L. Lattuada and G. Lux, Tetrahedro. Letters., 44, 3893 (2003). |
| 저자 | 임낙현1, 이하영1, 김문석1, 강길선2, 이해방1, 조선행1, 서성미3, 이봉3 |
| 소속 | 1한국화학(연), 2전북대, 3부경대 |
| 키워드 | polysuccinimide; micelle; MRI; contrast agent; biocompatible |
