| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Ultrasound (US) and glutathione (GSH)-responsive perfluorocarbon (PFC) nanocarrier for dual nitric oxide (NO)/drug delivery |
| 초록 |
Cancer is widely known as a fatal disease and global risk factor in current scenario. Among the key challenges in the successful treatment of cancer patients is the issue of precise targeting and drug delivery. Nitric oxide (NO) can induce vasodilation and improve membrane fluidity of cancer cell, which resulting in enhancement of EPR effect and precise target drug delivery. We developed a nanometer-sized multifunctional carrier for the GSH and US responsive PFC nanocarrier that can deliver dual NO and anticancer drugs for powerful & effective chemotherapy. We used ABA triblock copolymer consisting of a hydrophilic central PEG block and two terminal hydrophobic blocks of a polymethacrylate having pendant disulfides (PHMssEt). Furthermore, we investigated that degradation and release profiles of nile red (NR) and doxorubicin (DOX) loaded PFC nanocarrier depending on ultrasound treatment and cellular concentrations of GSH in cancer cells. |
| 저자 |
최문현, 노승만
|
| 소속 |
한국화학(연) |
| 키워드 |
nanocarrier; nitric oxide; drug delivery; perfluorocarbon; anti-cancer
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| E-Mail |
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