| 초록 |
The enhanced permeability and retention(EPR) effect has been a solid basis of cancer targeting mechanism for the most nanomedicines. However, the recent clinical trials revealed that the efficiency of the passive targeting was often too low to achieve enough intra tumoral drug accumulation. To address such an issue, we designed nitric oxide-generating nanoparticles(NO-NOs) to boost EPR by specifically dilating tumor blood vessels. The NO-NPs were prepared from self-assembly of copolymers, consisting of poly(ethylene glycol) and nitreated dextran, under aqueous condition. We successfully demonstrated the in vitro GSH-stimulated NO release from NO-NPs and their in vivo vasodilation effect on tumor vasculature after systemic administration. Furthermore, we confirmed superior in vivo therapeutic efficacy of doxorubicin (Dox)-loaded NO-NPs over the control groups in tumor-bearing mice with increased intratumoral DOX content, suggesting that the NO-NPs may act as a universal EPR enhancer. |
