| 초록 |
Photoinduced energy transfer has been widely investigated for biomedical applications such as fluorescence imaging, photoacoustic tomography, photothermal and photodynamic therapy. In this work, we successfully developed an optically active polymer of melanoidin as a new class of contrast agents for photoacoustic imaging and photothermal therapy. Melanoidin was prepared by non-enzymatical polymerization of glucose and glycine at 37 oC and pH 7.4 to avoid the formation of cytotoxic and mutagenic compounds. The prepared melanoidin was successfully applied to photoacoustic imaging of sentinel lymphatic node, bladder, and gastrointestinal tract. The photo-ablation therapy in tumor model mice was also successfully performed using melanoidin and melanoidin complex chelated with iron ions. Melanoidin was biodegradable and removed from the body by renal clearance. These results demonstrate the feasibility of optically active melanoidin for further clinical applications. |
