| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Effect of Ultrasound Stimulation on In Vitro Differentiation of Mesenchymal Stem Cells Loaded in Alginate/Hyaluronic Acid Hybrid Hydrogels |
| 초록 |
Ultrasound is described as an acoustic pressure wave that can transfer mechanical energy into tissue and cause biochemical events that are beneficial to the cell. In our previous study, injectable alginate (ALG)/hyaluronic acid (HA) hybrid hydrogels with time-dependent sol-gel transition showed the positive bone regeneration behavior. In this study, human bone marrow-derived mesenchymal stem cell (hMSC)-loaded ALG/HA hydrogels with different ALG/HA ratio (10/0, 9/1 and 8/2) were subjected to pulsed ultrasound stimulation. ALP and qRT-PCR analyses showed that hMSCs showed increased cell proliferation (DNA content) with increasing HA content in the hydrogel. The ultrasound-stimulated hydrogel groups showed more enhanced differentiation of the hMSC into chondrocyte (Type II collagen) and osteoblast (Osteopontin) than the hydrogel groups without ultrasound stimulation. |
| 저자 |
김세현1, 김호용2, 오세행2, 이진호1
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| 소속 |
1한남대, 2단국대 |
| 키워드 |
Ultrasound; Hydrogel; Differentiation of hMSC
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| E-Mail |
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