| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Integration of cell-derived ECM and polymer toward therapeutic applications |
| 초록 |
Extracellular matrix (ECM) is a complex but highly organized network of diverse macromolecular components that play a critical role in maintaining tissue homeostasis. To harness the great benefits of ECM toward therapeutic purposes, we have utilized human lung fibroblast-derived ECM (hFDM) that is obtained after decellularization of in vitro-cultured cells. These hFDMs are further processed to make a physical integration with biocompatiable synthetic polymers. This presentation is composed of two separate topics; 1) A novel platform of cardiomyocytes culture and co-culture via fibroblast-derived matrix-coupled electrospun nanofiber, and 2) Fabrication of stretchable ECM cardiac patch and its application to myocardial infarct. Taken together, cell-derived ECM-coupled polymeric biomaterial can provide not only an excellent microenvironment for cell adhesion and differentiation but may reinforce a therapeutic efficacy of human mesenchymal stem cells. |
| 저자 |
박귀덕1, 김인걸1, Muhammad Suhaeri1, Ramesh Subbiah1, 김종현1, 최동훈2
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| 소속 |
1한국과학기술(연), 2연세대 |
| 키워드 |
Cell-derived ECM; cardiomyocyte; co-culture; cardiac patch; myocardial infarct
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| E-Mail |
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