| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Doxorubicin releasing PLGA/PMA microparticles for MT1-MMP targeting of hepatic cancer |
| 초록 |
We demonstrated that the MT1-MMP-responsive peptide and DOX-conjugated PLGA/pSMA core/shell microparticles can be applied for intrahepatic arterial injection for hepatocellular carcinoma. PLGA/pSMA MPs were prepared with a capillary-focused microfluidic device. The particle size, observed by SEM, was around 22±3 μm. MT1-MMP-responsive peptide and DOX were chemically conjugated with pSMA segments on the shell of MPs to form a PLGA/ pSMA-peptide-DOX complex, resulting in high encapsulation efficiency(91.1%) and loading content(2.9%). DOX was released from PLGA/pSMA-peptide-DOX MPs in a pH-dependent manner(~25% at pH5.4 and ~8% at pH7.4) and accumulated significantly in an MT1-MMP over-expressing Hep3B cell line. An in vivo intrahepatic injection study showed localization of MPs on the hepatic vessels and hepatic lobes up to 24hrs after the injection without any shunting to the lung. Moreover, MPs efficiently inhibited tumor growth of Hep3B hepatic tumor xenografted mouse models. |
| 저자 |
김대현, 양수근, Yixin Jiang, 이정한
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| 소속 |
인하대 |
| 키워드 |
microparticle; poly-(D; L-lactide-co-glycolide); poly(styrene-alt-maleic anhydride); doxorubicin; hepatoma
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| E-Mail |
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