| 초록 |
In this study, we developed sustained oxygen-releasing polymeric microspheres and fabricated a sponge type by embedding the microspheres into alginate-based hydrogel that can supply oxygen to wound. Biocompatibility was performed using cell counting kit-8. The oxygen release kinetic study was performed using a hydrogen peroxide assay kit, SOD kit and oxygen meter. In vivo studies were carried out to investigate the safety and efficacy of the oxygen released hybrid scaffods for wound healing. As a result, the hybrid scaffolds demonstrated sustained release of oxygen for seven days in a physiologically favorable range, biocompatibility with HaCaT cells. Furthermore, Oxygen generating hybrid sponge appeared to delay the wound healing. And this may occur through the interference with re-epithelialization, wound contraciton and wound healed. Consequently, this newly manufactured hybrid footplate has great potential as a wound healing material for unique properties. |
