| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-고분자 |
| 제목 |
Synthesis of thermal responsive and fast-forming Chitosan hydrogels via inverse electrons demand Diels-Alder click reaction using for injectable implant applications |
| 초록 |
A novel chemically cross-linked hydrogel was successfully synthesized based on norbornene-functionalized Chitosan (Cs-Nb) and bis tetrazine Poly(N-Isopropylacrylamide) via inverse electrons demand Diels-Alder reaction between tetrazine and norbornene. Chitosan-norbornene were cross linked with bis-tetrazine PNIPAM with various molecular weight of PNIPAM to investigate the thermal sensitive and cumulative release. Chitosan was modified the primary amine group by norbornene carboxylic to form Cs-Nb proved by 1H NMR, FTIR spectrum; the degree of substitution (DS) of Nb was 10%. Beside, PNIPAM-Tz was prepared from tetrazine hydroxyl and dicarboxylic PNIPAM. The results hydrogels were characterized by SEM, swelling capacity, turbidity and cumulative release of Doxorubicin. Hydrogels showed swelling-shrink behaviors as temperature responsive, pH-sensitive, biocompatibility and fast forming in room temperature; these behaviors are greatly promising for injectable implant applications. |
| 저자 |
박한솔, Hoang Thi Huong, 조성우, 임권택
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| 소속 |
부경대 |
| 키워드 |
Chitosan; hydrogel; Diels-Alder; click reaction; thermal responsive; injectable implant
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| E-Mail |
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