| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Hyaluronic acid induced nanostructural changes in polypeptide thermogel promote 3D culture of chondrocytes |
| 초록 |
Hyaluronic acid is the component of extracellular matrix of articular cartilage. To investigate the effect of the HA in the tissue engineering application, we cultured chondrocytes in a 3D matrix of polypeptide thermogel. Cryo-TEM image of the gel showed that the incorporation of the HA in the polypeptide thermal gel induced the nanobundle formation in the hydrogel which can mimics the natural extracellular matrix of the articular cartilage. Compared with the thermogel without HA, the HA incorporated thermogel decreased the gel modulus, however cell proliferation and biomarker expression such as sulfated glucoaminoglycan and type II collagen for articular cartilage were significantly improved by using the HA as an excipient of the thermoal gel during the 3D culture. |
| 저자 |
박민희, 연보라, 정병문
|
| 소속 |
이화여자대 |
| 키워드 |
hyaluronic acid; thermogel; 3D culture; chondrocyte
|
| E-Mail |
|
