| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Intradermal Co-delivery of Plasmid DNA and Adjuvant using Dissolving Microneedles for Enhanced Cancer Immunotherapy |
| 초록 |
Microneedles(MNs) is desired as a non-invasive manner to deliver the therapeutic agents through stratum corneum, safely and painlessly. Among them, dissolving MNs is usually fabricated by biocompatible materials that can dissolve in the interstitial fluid of the skin. Herein we developed an amphiphilic copolymer Pluronic F127 (F127) based nano micelle to generate the MNs loading the hydrophobic adjuvant R848 and DA3/pOVA polyplex. DA3/pOVA polyplexes and F127/R848 micelles were released in the epidermis/dermis and a portion of F127/R848 micelles were also drained to the lymph nodes, which generates relatively superior cellular and humoral responses. R848 treated MNs group enhanced the OVA specific antibody level and intensity of IFN γ+CD 8 +T cells, which exhibited a remarkable effect on OVA specific cancer vaccine. Therefore, dissolving MNs encapsulating DA3/pOVA polyplex and R848 could be convenient and safe vaccination method with enhanced vaccine efficacy for cancer immunotherapy. |
| 저자 |
임수연, 김다훤, 정재백, 조희주, 김동민, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
microneedle; immunotherapy; cancer vaccine; polyplex
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| E-Mail |
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