| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 | 28권 1호, p.55 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | DRUG NANO- AND MICROPARTICLES PROCESSED INTO SOLID DOSAGE FORMS USING HYDROXYPROPYL CELLULOSE |
| 초록 | The use of nanoparticles of relatively insoluble drugs has enormously widened the window of achievable pharmacokinetic performance. For the successful development of this technology, it is essential to understand the characteristics of nanoparticles. In this study, the processability and solid dosage performance of nanoparticulates are compared with those of microparticulates. Nanoparticle suspensions are first prepared by wet comminution in the presence of stabilizers. Spray drying converts them into dried particles from which compacts are prepared. Nanoparticles easily form aggregates during spray drying. These aggregates can be slowly re-dispersed into nanoparticles in water. Compacts show differences in their internal structure and micro-mechanical deformations, according to the size of their primary particles. Stress to break and indentation hardness are found to be only slightly higher in nanoparticulate systems. References 1. Lee, R.W.; Mcshane, J.; Shaw, J.M.; Wood, R.W., 2000, Particle size reduction, In Water-insoluble Drug Formation, Liu, R. editor; Interpharm Press, Buffalo Grove, p455-492. 2. Liversidge, G.G.; Conzentino, P.; 1995, Drug particle size reduction for decreasing gastic irritancy and enhancing absorption of naproxen in rats, Int. J. Pharm., 125: p309-313. 3. Liversidge, G.G.; Cundy, K.; 1995, Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs, Int. J. Pharm. 125: p91-97. 4. Merisko-Liversidge, E.; Sarpotdar, P.; Bruno, J.; Hajj. S.; Wei, L.; Peltier, N.; Rake, J.; Shaw, J.M.; Pugh, S.; Pollin, L.; Jones, J.; Corbett, T.; Cooper, E.; Liversidge, G.G.; 1996, Formulation and antitumor activity evaluation of nanocrystalline suspensions of poorly soluble anticancer drugs, Pharm. Res.; 13: p272-278. |
| 저자 | 이종휘 |
| 소속 | Merck Research Laboratories |
| 키워드 | Nanoparticles; Drug; Physical Properties; Solid Dosage Forms |
