| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Preparation of multi-channel neural guidance platform and axonal growth control by various factors |
| 초록 |
Peripheral Nervous System(PNS) has a limited ability to regenerate after a traumatic injury. Autologous nerve grafts or nerve allografts remain as the current primary treatment method. However availability of autologous nerve grafts is limited and allografts cause immunogenic problems. Thus researchers have developed neural guidance for the nerve regeneration. In this study, we developed a neural guidance platform to control the axonal growth. We prepared the three-dimensional nerve guidance with the micro-sized hollow channels using Poly Ethylene Glycol as a raw material. Channels are engraved with aligned patterns which mimic a natural extracellular matrix and coated with Polypyrrole which is a conductive polymer. Other studies have shown that neuronal deficits were restored when neurons are cultured on a certain directional surface with electrical stimulations. Therefore, our system have structures that give physical and electrical cues for the growth of axon. |
| 저자 |
강성민, 윤병주, 이경민, 김지영, 고원건
|
| 소속 |
연세대 |
| 키워드 |
neural guidance; axonal growth
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| E-Mail |
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