| 초록 |
Molecular luminescence has made significant contributions to advances of biomedical sciences as a powerful analytical and diagnostic tool that allows a closer access to biological and pathological processes. In this presentation, luminescent (fluorescent, phosphorescent or chemiluminescent) molecular nanoparticles will be introduced as a new class of all-organic biophotonic nanosensors. Multi-molecule integration approach offers a nanoscopic reactor system where sensing reaction can occur efficiently in response to disease-related analytes. Advanced π-conjugated molecules and polymers were designed, synthesized and formulated into water-dispersed polymer nanoparticles capable of emitting intense sensing signals as well as in vivo disease targeting. Features of imaging signal amplification and disease-specific functionalization will be discussed, along with their biomedical in vivo applications to passive and functional diagnostic imaging in cells and murine disease models. |
