| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The role of multi segmented metallic nanorod in immune cell culture |
| 초록 |
Multi segmented nanorods applied to gene and drug delivery due to their unique morphological features. Various ligands can be precisely decorated on the each segment of the nanorods without disrupting adjacent segments by different conjugation chemistry. We electrodeposited the nanorods composed of gold and nickel segments and surface-decorated the nanorods with two different ligands which are recognized by immune cells. Mannose and GRGDS peptide were simultaneously conjugated on the surface of gold and nickel segments, respectively, which can be served as anchorages for antigen presenting cells (APCs) and immature T cells. Conjugation of the ligands was characterized by confocal microscopy analysis. Surface-decorated nanorods with Jurkat cells, immortalized human T lymphocytes, CD11c+ bone marrow dendritic cells from C57B/6 mice were added to the incubation medium. The levels of cytokines such as interleukin (IL)-2 were determined by an enzyme-linked immunosorbent assay (ELISA). |
| 저자 |
손영주, 최지숙, 김혜성, 윤수진, 조은주, 김영희, 유혁상
|
| 소속 |
강원대 |
| 키워드 |
multi-segmented nanorod; antigen presenting cell; T cell; cell ligand
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| E-Mail |
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