| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Electrospun nanofibrous mesh including catechol-modified poly (ethylene glycol) and thiolated poly (lactic-co-glycolic acid) for anti-fouling tissue adhesive |
| 초록 |
Tissue adhesives using electrospun nanofibrous mesh (NF) can be applied to the suture site after surgery as an ‘anti-adhesive barrier’. In order to achieve anti-fouling effect and adhesiveness to tissue surface, catechol moiety was conjugated to 8-arm poly (ethylene glycol) (PEG). Electrospun PLGA-SH/cPEG NF was prepared by electrospinning with catechol-modified 8-arm PEG (cPEG) (Mw 20,000) and thiolated poly (lactic-co-glycolic acid) (PLGA-SH) (Mw 20,000; lactide:glycolide=75:25) dissolved at concentration of 40% (w/v) in chloroform and methanol mixture (3:1). For cross-linking, sodium periodate (3mM) was treated to NFs and completely dried for overnight. We confirmed cross-linking between catechol moieties and thiol groups by differential scanning calorimety and raman spectroscopy. Cross-linked NF showed good anti-fouling effect on biomolecules and also showed delayed mass erosion rate, which suggests that mechanical strength was increased by cross-linking. |
| 저자 |
윤수진1, 최지숙1, 김혜성1, 손영주1, 조은주1, 김영희1, 강지현1, Phillip B. Messersmith2, 유혁상1
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| 소속 |
1강원대, 2Northwestern Univ. |
| 키워드 |
nanofiber; catechol; PEG; PLGA; anti-fouling
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| E-Mail |
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