| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Preparation and Characterization of Doxorubicin-loaded Redox-sensitive Polymeric Nanoparticle Based on Water Soluble Chitosan for Cancer Therapy |
| 초록 |
Recently, number of researcher developed to drug carrier in order to delivery of hydrophilic and hydrophobic substance in order to drug delivery in cancer cell. However, To solve these problem, redox-sensitive polymeric micelle was synthesized by coupling reaction between lipoic acid and water soluble chitosan (WSC). Redox-sensitive polymeric micelle has an advantage of trigger-drug release by glutathione (GSH) into cancer cell. Chemical structure of LA-grafted water soluble chitosan (LWSC) was confirmed by 1H-NMR and FT-IR. Its critical aggregation concentration (CAC) was analyzed by fluorophotometer. Also, Doxorubicin (DOX)-loaded WSC (DLWSC) nanoparticles were produced by dialysis method. Moreover, Cytotoxicity and anticancer activity were conducted by using MTT assay. These results suggest that redox-sensitive DLWSC is a superb anticancer agent for cancer therapy. (NRF-2016H1D5A1910499). |
| 저자 |
남충현1, 안준혁1, 김태훈2, 홍웅길1, 정경원1, 박준규2, 나재운1
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| 소속 |
1순천대, 2시지바이오 |
| 키워드 |
Water soluble chitosan; Lipoic acid; Doxorubicin; Redox-senetive
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| E-Mail |
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