| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
고분자합성-구조제어중합 |
| 제목 |
Synthesis and Characterization of New DNA-Mimic Brush Polymers Bearing Adenine Moieties |
| 초록 |
In this study, we describe new well-defined DNA-mimicking brush polyoxyethylenes bearing adenine moieties at the bristle ends : poly[oxy(11-(3-(9-adeninyl-propionato)-undecanyl-1-thiomethyl)ethylene](PECH-AP) and poly[oxy(11-(5-(9-adenylethyloxy)-4-oxopentanoato)undecanyl-1-thiomethyl)ethylene](PECH-AS). these polymers were found to be thermally stable up to 220 °C and could be applied easily by conventional coating processes. Interestingly, both brush polymers formed molecular multi-bilayer structures. PECH-AS surprisingly exhibited higher hydrophilicity and better water sorption properties than PECH-AP. The adenine-rich surfaces demonstrated facilitated HEp-2 cell adhesion, suppressed bacterial adherence, selective protein adsorption, and exhibited good biocompatibility in mice. However, the high hydrophilicity and good water sorption characteristics of the PECH-AS film suggest that this brush polymer is better suited to applications requiring good biocompatibility. |
| 저자 |
권경호1, 김진철1, 정정운1, 노예철1, 김미희1, 권원상1, 김경태1, 김동민1, 안병철1, 정성민1, 고용기1, 김영용1, 함석규1, 김희수2, 김익정2, 김정란2, 이문호1
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| 소속 |
1포항공과대, 2동국대 |
| 키워드 |
Synthesis; Layer-by-Layer Self-Assembly; Biocompatibility
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| E-Mail |
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