| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
고분자구조 및 물성 |
| 제목 |
pH and reduction triggered poly(histidine) coated mesoporous silica nanoparticles for targeted delivery of curcumin |
| 초록 |
Curcumin encapsulated mesoporous silica nano particles (MSNPs) attached with poly(histidine) (pHis) and poly(ethylene glycol) (PEG) through disulphide linkages and investigated their pH and reduction triggered release behavior. The enhanced CUR release showed at intracellular environment by degradation of pHis and PEG under glutathione (GSH) than extracellular environment. The cell viability results of CUR loaded MSNPs showed high anticancer activity towards MCF-7 cancer cells. The cellular uptake of coated MSNPs mainly caused targeting ability of pHis for MCF-7 cells. Hence, these results suggest that the pH and reduction triggered MSNPs offer versatility for intracellular targeted drug release of hydrophobic drugs in cancer therapy. |
| 저자 |
하창식, 윤양현, 라오
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| 소속 |
부산대 |
| 키워드 |
mesoporous; nanoparticles; coating; poly(histidine); cell internalization; curcumin; and anticancer activity
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| E-Mail |
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