| 초록 |
Liquid metal particles are widely used in bioengineering applications as well as soft electronics. Especially, eutectic gallium-indium alloy (EGaIn) has excellent chemical stability and biocompatibility. Upon near infrared (NIR) radiation, the elevation of temperature as well as the formation of reactive oxygen species (ROS) leads EGaIn to be utilized in cancer treatment platform. Herein, a interpenetrating network (IPN) hydrogel with 6- mercaptopurine (6-MP) attached thiolated gelatin (GSH) and poly(ethylene glycol) diacrylate was used as an injectable reservoir for EGaIn mediated multiple anti-cancer treatments: (1) photothermal effect, (2) photodynamic effect by ROS, and (3) additional delivery of anti-cancer drug 6-MP. Therefore, our injectable IPN hydrogel platform containing EGaIn particle and chemical drug could be applied to a multi-functional anticancer therapy. |
