| 초록 |
Injectable alginate hydrogels offer a wide range of attractive benefits, as an easy-to-use medical device for various applications. In this work, injectable alginate hydrogels were fabricated by modification of alginate with tyramine and subsequent enzymatic crosslinking reaction with horseradish peroxidase and hydrogen peroxide. The modified alginate was analyzed by ATR-FTIR, 1H-NMR in order to confirm the modification of alginate with tyramine. Rheological properties were tested for adjusting the amount of reagents. The results for gelation time and mechanical strength revealed that both the rate and degree of cross-linking in alginate hydrogels were well controlled by concentrations of the H2O2 and HRP. And the degradation rates were also controllable by adjusting the degree of cross-linking. Application of fabricated alginate hydrogel to wound healing materials is now in progress. |
