| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ |
| 제목 |
Hyaluronic acid-based hydrogel microparticles for enhanced local retention of radioisotopes |
| 초록 |
Radioisotopes provide diagnostic imaging and disease treatment for various diseases including cancer. In order to overcome the limitations of targeted radiation therapy using radioactive isotopes, long-term low-dose radiation therapy was performed by encapsulating the isotope in an injectable hydrogel. However, the difficulty of fabrication of radioactive hydrogels and unpredictable levels of radioactivity at the target site are major obstacles to clinical use. In this study, we developed the radioactive microgels using a 131I-labeled photocrosslinkable hyaluronic acid (HA) and a high-throughput microdroplet generator. This approach allows rapid fabrication of injectable, radioactive, biodegradable(IRB) HA microgels, enabling immediate treatment with improved local retention. We demonstrated the clinical utility of this comprehensive approach by preparing IRB HA microgels within 15 minutes and localizing retention with minimal biodistribution beyond 2 weeks in target tissues in vivo. |
| 저자 |
김소담1, 임상구1, Ajeesh Chandrasekharan1, 성금용1, 이태욱1, 김병연2, 김근영1, 최성용2, 양승윤1
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| 소속 |
1부산대, 2한양대 |
| 키워드 |
Injectable drug delivery system; radiotherapy; hyaluronic acid; 131I; hydrogel microparticle
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| E-Mail |
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