화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2021년 봄 (04/21 ~ 04/23, 부산 BEXCO)
권호 27권 1호, p.175
발표분야 고분자
제목 Biphasic Nano-Domain Model Derived from Molecular Dynamics of Phospholipid-Diacetylene Complex Bilayer forAntimucrobial Detection
초록 Polydiacetylene (PDA), one of the responsive polymers, is an attractive material for sensors, bio-imaging and drug delivery system. By assigning this material, exhibiting blue-to-red color transition due to external stimuli, to supported lipid bilayer platform, it delivers selectivity in bio-molecular detection.To investigate time-dependent nanoscale phase behavior and color transition after antimicrobial peptide injection on SLB system, we adapted computational chemistry, especially coarse-grained (CG) molecular dynamics simulation. We conducted CG simulation with antimicrobial peptide on phospholipid-diacetylene system to present a crucial role of in regulating the degree of phase coexistence. In this study, we confrimed that the liquid-disordered phase of the system plays a critical role on increased detection capability against peptide.
저자 정우혁, 황지민, 안동준
소속 고려대
키워드 첨단고분자
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