| 초록 |
In recent years, nitric oxide (NO) has been studied extensively due to its unique pleiotropic nature and importance in maintaining a healthy vasculature. At high concentrations NO inhibits the growth of cells, such as smooth muscle cells. In contrast, at low concentrations it promotes growth of cells, such as endothelial cells. Due to its very short half-life, it’s very difficult to fabricate local sustained release systems using it, thus the use of phospholipid bio-interfaces to control NO release could be a solution. Liposomes and tethered lipid bilayers were used in an attempt to control three types of NO donors or generators (hydrophillic, hydrophobic and NO generating catalyst). NO release profiles unveiled controlled release over a time span of 7 days. |
