| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Application of Pristine Nitrogen and Sulfur Doped Carbon Quantum Dots for Detection of Glutathione and Reduction of Nitric Oxide in LPS induced Microglial cells |
| 초록 |
Glutathione (GSH) , a tripeptide and a potent anti-oxidant has been expressed in the cells and is involved in diverse biomedical reactions. However, under certain disease conditions like cancer, their levels are elevated in the cells resulting in abnormal cellular activity. Here we developed nitrogen and sulfur doped pristine carbon quantum dots (CQDs) as a novel biosensor for GSH detection. The developed CQDs demonstrated excitation independent emission, indicating that the fluorescence from CQDs is resulted from surface functional groups. The fluorescence of CQDs were selectively reduced only in the presence of GSH. Interestingly, the developed CQDs reduced the levels of nitric oxide (NO), a potent pro-inflammatory cytokine in the LPS induced microglial cells. The results indicate a 50% reduction in the NO production when the cells were incubated with CQDs. These results demonstrate CQDs as potent biological nanomaterials for diverse biomedical applications. |
| 저자 |
안정만, Jagannth Mondal, Vishnu Revuri, 강우정, 이용규
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| 소속 |
한국교통대 |
| 키워드 |
Glutathione; LPS; Nitric Oxide; Carbon Quantum Dots
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| E-Mail |
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