| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Thermo-dependent structure change polymer for improved tumor therapy |
| 초록 |
The Photosensitizer (PS) used in the Photodynamic therapy (PDT) produces ROS when the laser is irradiated and causes damage. PS has hydrophobic properties, aggregates in water, resulting in quenching of photoactivity. So, we had to foam an environment where PS was not quenched. In this study, the temperature-dependent change polymer was combined with PS (TDCPP). TDCPP heated up, it was changed Random-coiled form to collapsed form. Then, nonpolar environment is created between the TDCPs and PSs were changed quenching to monomeric state. As a result, the photoactivity will be significantly improved. Increasing the temperature allows both thermotherapy and PDT to work at the same time, synergistically treating cancer. At various temperature, small-angle X-ray scattering was used to confirm the structural change. Singlet oxygen generation test confirmed that more ROS generation occurred at 45 °C. Live/dead assays showed more toxicity at higher temperatures. |
| 저자 |
임병준1, 박우람1, 박신정1, 신희준1, 정영석1, 이충성1, 이병두2, 김동현3, 나건1
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| 소속 |
1가톨릭대, 2Argonne National Laboratory, 3Northwestern Univ. |
| 키워드 |
Photo dynamictherapy; Tumor microenvironment
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| E-Mail |
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