| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I (영어발표) |
| 제목 |
Non-degradable cell encapsulation with alginate-EGCG conjugation (Green BeadTM) |
| 초록 |
Immunoprotective microencapsulation with alginate has been developed for cell transplantation. However, pure alginate microencapsulation techniques have a limitation in that Ca2+-alginate hydrogel slowly dissolve in the body and induce hypoxia to encapsulated islets. To overcome these limitations, we conjugated epigallocatechin gallate (EGCG) to alginate, which is capable of forming aggregates by auto-oxidation, independent of Ca2+. We confirmed that the surface-modified microcapsules could have stronger physical properties than the conventional alginate microcapsules. In addition, the surface modification of the microcapsules (Green BeadTM) was performed once again using alginate for the suppressed immune response. Also, they showed the effect of radical scavenging. Subsequently, the immune response of the body through the transplantation of Green BeadTM with islets and their therapeutic effect on diabetic animals was confirmed. |
| 저자 |
Jae Bin Lee1, Jae-Kyung Park2, Kimyung Choi2, Dong Yun Lee1
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| 소속 |
1Hanyang Univ., 2Optipharm Co. Ltd. |
| 키워드 |
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| E-Mail |
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