| 초록 |
Sterically crowded vicinal acid-amide (i.e. maleic acid-amide) system shows pH-responsive degradability to release free amines in relatively mild acidic conditions. This unique feature can be applied into pH-responsive drug delivery. In this research, we focused on synthesizing polymers containing the vicinal acid-amide system. To minimize the synthetic steps for carrier-linker conjugation and to increase the amine loading density, we intended to prepare polymers possessing maleic anhydride derivatives in the backbone. Therefore, monomers were designed to contain a strained ring structure and polymerized via ring opening metathesis polymerization using the 2nd generation Grubbs catalyst. After grafting with propylamine, the pH-responsive degradation of the polymers was analyzed by quantification of released amine from the polymers in various pH conditions. Furthermore, we compared in vitro bioactivity of alendronate-grafted polymers using breast cancer cell at pH 5.5 and 7.4. |
