| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Poly(L-histidine)-Tagged 5-Aminolevulinic Acid Prodrugs: New Photosensitizing Precursors of Protoporphyrin IX for Photodynamic Therapy |
| 초록 |
5-Aminolevulinic acid (ALA) and its derivatives have been widely used in photodynamic therapy (PDT). The main drawback associated with ALA-based photodynamic therapy (ALA-PDT) and ALA fluorescence diagnosis results from the hydrophilic nature of ALA and lack of selectivity for tumor versus nontumor cells. To improve the selectivity, a series of pH-sensitive ALA-poly(L-histidine) [p(L-His)n (n=5,10,15)] prodrugs were synthesized via ring opening polymerization of 1-benzyl-N-carboxy-L-histidine anhydride initiated by the amine hydrochloride group of ALA itself. As an alternative to ALA for PDT, these prodrugs were used to treat a cultured human colon cancer HCT116 cell line under different pH conditions. The effect of ALA-p(L-His)n derivatives was evaluated by monitoring the fluorescence intensity of protoporphyrin IX, and measuring the cell survival rate after suitable light irradiation. |
| 저자 |
렌지스1, 김일2, 강대환1, 정정욱2
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| 소속 |
1부산대, 2합성고분자 생물접합 하이브리드 재료사업단 |
| 키워드 |
5-Aminolevulinic acid; Photodynamic therapy; Poly(L-histidine); Bioconjugate; Cancer cells
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| E-Mail |
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