| 초록 |
To achieve control of stem cell fate, fine-tuned biocompatible scaffolds with bioactive molecules are necessary. Herein, we develop fine-tunable and injectable 3D hydrogel system with use of thermosensitive poly(organophosphazene) bearing β-cyclodextrin and two types of adamantane-peptides (Ad-peptides) that are associated with MSC differentiation that serve as stoichiometrically controlled pendants for fine-tuning. Given that complexation of hosts and guests subject to strict stoichiometric control is achieved with simple mixing, these fabricated hydrogels exhibit well-aligned, fine-tuning responses. Injection of MSCs in fine-tuned hydrogels also results in various chondrogenic differentiation levels. This is attributed to differential controls of Ad-peptides, if MSC preconditioning is excluded. Eventually, our fine-tunable and injectable 3D hydrogel could be applied as platform technology by simply switching types of peptides bearing adamantane and their stoichiometry. |
