| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Preparation and Characterization of Chitosan-coated PLGA nanoparticle |
| 초록 |
The amphipathic PLGA is a FDA-approved to biocompatibility polymer. It is broadly used as drug delivery carrier of insoluble drugs. However, PLGA nanoparticle in oral delivery system has many problem including unstable particle and inefficient absorption in intestinal mucosa. To overcome these obstacle, chitosan was coated to PLGA nanoparticle, which may lead to enhanced bioavailability. Chitosan-coated PLGA nanoparticle (CPN) was prepared by w/o/w emulsion method. Its chemical structure was analyzed by 1H-NMR and FT-IR. In addition, its particle size and zeta potential were measured by DLS. Moreover, morphological property of CPN was observed by TEM. The thermal analysis of CPN was confirmed by TGA and DSC. Besides, cytotoxicity of CPN were assessed by MTT assay. These results suggest that CPN is superb drug carrier in oral delivery system. (No. NRF-2016H1D5A1910499). |
| 저자 |
유수경, 홍웅길, 안준혁, 김준수, 정경원, 나재운
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| 소속 |
순천대 |
| 키워드 |
Chitosan; PLGA; Oral delivery system; Bioavailability
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| E-Mail |
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