| 초록 |
Patches for the treatment of myocardial infarction, implanted into the heart, must be biocompatible and biodegradable with a certain level of elasticity. Therefore, this study synthesized 3D patch material and then proceeded to filament extrusion and 3D printing. Polyethylene glycol, polycaprolactone, and polylactid were used as biocompatible and biodegradable materials. By controlling the PEG content, PCL-PEG-PCL and PLA-PCL-PEG-PCL-PLA blockcopolymer were synthesized and then polyurethane(PU) was synthesized. The structure and polymer growth of the block copolymer was confirmed by 1H NMR and GPC. Also, the chemical bond was confirmed through FTIR. PU properties according to the PEG composition and PLA addition was confirmed by UTM. In the biodegradability test, tensile strength change, weight loss and appearance change were compared over time. After confirming the Tm through DSC analysis, the filament was extruded, and the desired patch shape was finally produced using a 3D printer. |
