| 초록 |
Vascular disease can be fatal and therefore rapid treatment is required. Stent, mechanically widening the blood vessels narrowed by aging and waste, can cause tissue damage, restenosis, and thrombosis. Drug delivery platforms can be degraded in vivo to overcome these challenges. Drug delivery to topical sites in the blood vessels using complex coacervate system is biodegradable and enhance adhesiveness, local delivery. Hyaluronic acid is an immunoneutral polysaccharide that is ubiquitous in the human body and has been in clinical use for biocompatible material. Chitosan has been an attractive biomaterial for clinical applications. We will synthesize biocompatible adhesive gallol conjugated hydrogels by synthesizing with ‘Pyro gallol’ and which can show mucoadhesion and adhesiveness in water environment. AAV (adeno-associated virus) is introduced into the complex coacervate to study biomaterials that local drug delivery, sustained drug release, and biodegradation in vivo. |
