| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ |
| 제목 |
Promoted Osteogenic Differentiation by MXene Nanosheets and Application to PLCL/Collagen Nanofibrous Matrices |
| 초록 |
MXene, one of the most emerging two-dimensional (2D) nanomaterials, has drawn increasing attention due to its unique physicochemical properties. Herein, the osteogenic potential of MXene nanosheets was explored and then they were incorporated into electrospun poly(L-lactide-co-ε-caprolactone)/collagen (PLCL/Col) nanofiber matrices to further investigate their synergistic activity for bone tissue engineering (BTE) scaffolds. It was found that MXene nanosheets were not cytotoxic to MC3T3-E1 preosteoblasts at lower than 31.3 μg/mL and significantly promoted their ALP activity without hampering cell growth. PLCL/Col matrices were shown to provide favorable environments for cell attachment. In conclusion, it is suggested that the PLCL/Col nanofiber matrices with MXene nanosheets can be promising candidates as novel scaffolds for BTE. |
| 저자 |
이석현, 강문성, 이지은, 김춘태, Selestin Raja Iruthayapandi, 홍석원, 한동욱
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| 소속 |
부산대 |
| 키워드 |
MXene; RGD Peptide; PLCL; Nanofiber Matrix; Bone Tissue Engineering
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| E-Mail |
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