| 초록 |
Poly(3-hydroxybutyrate)/poly(hydroxybutyrate-co-hydroxyvalerate) (PHB/PHBV) nanofiberous scaffolds with high porosity are increasingly being used in biomedical applications due to ability to mimic the the extracellular matrixes. However, the use of PHB/PHBV scaffolds are limited due to their low mechanical strength and strong hydrophoblicity. This study is to combine alginate with PHB/PHBV scaffolds prepared by non-solvent induced phase separation(NIPS) to in the mechanical strength and surface hydrophilicity. Alginate was incorporated into PHB/PHBV hydrogels and foams by solvent exchange and dip coating techniques. The effect of alginate concentration on the properties of hybrid scaffolds was investigated. The resulting hybrids caffolds exhibited the much increased compressive strength and hydrophilicity compared to neat PHB/PHBV scaffolds. The hybrid scaffolds were characterized by IR, contact angle, TGA, SEM and BET. The as-prepared scaffolds showed biocompatibility for MG-63 cells. |
