| 초록 |
Achieving significant adhesion to multiple soft tissues while minimizing tissue damage poses a considerable challenge in the clinic. In this talk I will present a swellable microneedle adhesive developing to provide a superior adhesion to wet tissues and minimal tissue damage based on mechanical interlocking with tissue. This new tissue adhesive, which is inspired by the ability of the endoparasitic worm to swell its proboscis and attach to the intestinal wall of host, achieves ~ 3.5 fold in adhesion strength compared to staples in skin graft fixation, and up to 4.5 N/cm2 with the mucosal surface of intestine tissue. This bio-inspired design can provide rapid universal soft tissue adhesion with minimal damage, less traumatic removal, reduced risk of infection and delivery of bioactive therapeutics. |
