| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 학생우수논문발표(석사과정) |
| 제목 | Addressing the Shortcomings of Polyphenol-derived Adhesives:Achievement of Long Shelf Life for Effective Hemostasis |
| 초록 | Polyphenol-containing hemostatic agents have been developed on a basis of generation of physically adhesive barrier between the material and the wound. However, for long-term storage of the agents, spontaneous oxidation of the polyphenols has been a challenge to secure stable hemostatic capability and robust adhesion. Here, we report a transparent hemostatic film consisting of gallol-conjugated chitosan(CHI-G) for minimizing the phenolic oxidation even for three months and maintaining strong tissue adhesiveness and its hemostatic ability. In particular, the film can show a phase transition from solid-to-injectable hydrogels at physiological pH for effectively stopping internal hemorrhage. When the hydrogels are originated from the dehydrated film,their successful and durable hemostasis is observed in liver bleeding model.Our finding would provide an insight for design rationale of the hemostatic formulations with long shelf-life. |
| 저자 | 주재원, 신미경 |
| 소속 | 성균관대 |
| 키워드 | Gallols; Film-to-hydrogel conversion; Long shelf-life; Durable hemostasis |
