| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Biological Study of Poly(propylene carbonate) Prepared from Copolymerization of Carbon Dioxide with Propylene Oxide. |
| 초록 |
In this study we investigated bacterial and cell adhesion to poly(propylene carbonate) (PPC) films, synthesized by copolymerization of carbon dioxide (a global warming chemical) with propylene oxide. We also assessed the biocompatibility and biodegradability of the films in vivo, and their oxidative degradation in vitro. It was found that there was adhesion of bacteria to the smooth, hydrophobic PPC surface after 4 h incubation. In contrast there was no adhesion of human cells (cell line HEp-2) to the PPC films, due to the hydrophobicity and dimensional instability of the surface. On the other hand, the PPC films exhibited good biocompatibility in the mouse subcutaneous environment. Moreover, surprisingly the PPC films were found to degrade in the mouse subcutaneous environment. This is the first time that PPC can undergo surface erosion biodegradation in vivo. The observed biodegradability of PPC may have resulted from enzymatic hydrolysis and oxidative degradation processes. |
| 저자 |
정정운1, 김가희2, 박삼대2, 진상우2, 김진철2, 김동민2, 노예철2, 안병철2, 권원상2, 김경태2, 김미희2, 고용기2, 이문호2
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| 소속 |
1포항공과 대, 2포항공과대 |
| 키워드 |
PPC; poly(propylene carbonate); biodegradation; biocompatibility
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| E-Mail |
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