| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
In situ Forming Hyaluronic Acid Hydrogels for the Treatment of Rheumatoid Arthritis |
| 초록 |
In situ forming tyramine modified hyaluronic acid (HA-Tyr) hydrogels were successfully developed for the treatment of rheumatoid arthritis (RA) with reactive oxygen species facilitating the hydrogel formation. HA-Tyr hydrogels were prepared for the encapsulation of dexamethasone (DMT) as a model RA drug by radical crosslinking reaction using hydrogen peroxide and horse radish peroxidase. According to in vitro release tests, DMT was sustained released from the HA-Tyr hydrogels up to a month. Intra-articular injection of the in situ forming HA-Tyr hydrogels encapsulating DMT resulted in successful treatment of RA with statistically significant reduction of IL-6, PGE2 and other cytokine levels in collagen-induced arthritis animal models. Histological analysis with hematoxylin & eosin staining also confirmed the therapeutic effect of injectable HA-Tyr hydrogel systems. The recovered cartilage after treatment with HA-Tyr hydrogels containing DMT was comparable to that of normal SD rats. |
| 저자 |
김기수, 박상준, 고은지, 한세광
|
| 소속 |
포항공과대 |
| 키워드 |
Hyaluronic acid; Tyramine; Hydrogel; Dexamethasone; Rheumatoid Arthritis
|
| E-Mail |
|
