| 초록 |
A sonodynamic therapy (SDT) has emerged as a promising alternative of photodynamic therapy, due to intrinsic properties of ultrasound such as deep penetration depth, its site-specific action. However, inaccurate positioning of the ultrasound can limit the therapeutic efficacy and occur side effects on neighboring tissues. Therefore, the treatment region of the ultrasound should be carefully defined. Here, we developed titania-coated mesoporous silica nanoparticles encapsulating perfluorohexane (PFH@TMSNs) that can generate reactive oxygen species and contrast the tumor tissues under ultrasound irradiation. Mesoporous silica nanoparticles are coated by titania surface coat for adding an ability to generate singlet oxygen under ultrasound, and an ultrasound imaging agent, perfluorohexane, is physically encapsulated into pores of mesoporous silica nanoparticles for tumor-specific contrast. |
