| 초록 |
Photodynamic therapy (PDT) for cancer, has been limited by low reactive oxygen species (ROS) quantum yield of photosensitizer (PS) and lack of the proper imaging system. Herein, we report a self-illuminating nanoparticles (SI-NPs) as a new theranostic agent based on chemiluminescence (CL) resonance energy transfer (CRET). Firstly, the SI-NPs are able to produce CO2 by responding to H2O2, which is abundant at tumor sites, occurring CRET. By heat energy from PS with pulsed laser, thermal expansion-induced vaporization of CO2 is proceeded, followed by amplifying the PA signal. Notably, SI-NPs generated 9 times stronger in vivo PA signal than the CRET-free NPs. Second, for successful PDT, the low ROS quantum yields of PS should be significantly improved. Since enhanced ROS quantum yields by CL and electron transfer can effectively inhibited tumor growth with complete regression in 60 % of cases in vivo. Overall, the SI-NPs might hold great potential phototheranositics for cancer. |
