| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
우수논문(구두)_박사과정 |
| 제목 |
Novel “Turn-On” Fluorescent Probes for the In Vivo Imaging and Detection of Hydrogen Sulfide |
| 초록 |
Hydrogen sulfide is a key endogenous signaling molecule in living systems and thus there is an urgency to develop a sensitive, selective and biologically compatible method for its in vivo detection. Here, we present the design, synthesis and demonstration of novel azide-functionalized fluorescent probes, visible and near-infrared fluorescent ligands, for a hydrogen sulfide assay in vitro and in vivo. The fluorescent probes were highly sensitive and selective toward hydrogen sulfide over biothiols, and other reactive sulfur, nitrogen, and oxygen species (16 analytes) in aqueous solution. By exploiting the excellent properties of the probes, such as the good biocompatibility and rapid cell internalization, we successfully demonstrated their usefulness in monitoring of hydrogen sulfide in living cells and animals, thereby providing a powerful approach for probing hydrogen sulfide chemistry in biological systems. |
| 저자 |
박철순1, 배준원2, 이창수3, 권오석2, 윤현석4
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| 소속 |
1전남대, 2한국생명공학(연), 3동덕여자대, 4위해요소감지 BNT연구단 |
| 키워드 |
Hydrogen sulfide; Fluorescent probe; in-vivo
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| E-Mail |
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