| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
생체재료 |
| 제목 |
Anticancer Drug Delivery of Functionalized Carbon Dots based Pluronic Guided Target Imaging |
| 초록 |
The carbonized polymer dots from Pluronic F-127 (P-PDs) show very unique morphological transformation in different concentrations as proved by monitoring TEM images at different concentrations and accomplish concentration-modulated multi-color fluorescence emission from blue to red even with constant excitation wavelength, which might originate from the aggregation-mediated reconstruction of surface energy traps of the P-PDs in different concentrations. With respect to imaging guided active target delivery, here we conjugated DOX drug via pH-sensitive linkage bond and targeting ligand FA on surface of P-PDs. The formulated DOX-NH2-PDs-FA showed increased cellular uptake of malignant KB cells compare to that of non-malignant MDCK cells suggesting a potential for targeting. Thus, we therefore achieved the concentration-dependent P-PDs for bio-imaging and target drug delivery of doxorubicin on cancer cell. |
| 저자 |
강은비, 이기백, 박성영
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| 소속 |
한국교통대 |
| 키워드 |
polymer dots (PDs); doxorubicin (DOX); target delivery; bioimaging; Pluronic |
| E-Mail |
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