| 학회 | 한국공업화학회 |
| 학술대회 | 2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 | 21권 1호 |
| 발표분야 | 나노 |
| 제목 | Blood-based breast cancer detection of miRNA in metastasis state using surface enhanced Raman scattering |
| 초록 | Blood-based detection of cancer has recently attracted a lot of interest. Of them, micro-ribonucleic acids (miRNAs) are the most promising biomarker for cancer diagnosis. We select target miRNAs for breast cancer in metastasis state (miR-10b, miR-21, miR-373). We developed a SERS-based method for direct detection of miRNA in breast cancer using blood samples. For highly-sensitive detection system, between two metal substrates, Plasmon coupling was generated and signal enhancement was conducted. As a result, using gold nanosphere and gold film-array, we fabricated nano-array with DNA probe chip. Based on these strategies, non-label miRNA detection system was developed as an advanced less tumor-invasive biopsy for diagnosis of breast cancer. This system supports that cell-free miRNAs in blood can be utilized as biomarkers to conduct tumor-oriented, rapid and high sensitive blood-based detection of breast cancer. |
| 저자 | 황성원, 김우현, 이종욱, 심상준 |
| 소속 | 고려대 |
| 키워드 | blood-based detection; breast cancer; miRNA; Raman scattering; metastasis state |
