| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
Synthesis and characterization of thermo-sensitive Poly (N-vinyl caprolactam) grafted with sodium alginate hydrogel beads for the controlled release of 5-FU |
| 초록 |
Graft copolymers of sodium alginate (NaAlg) with N-vinyl caprolactam were prepared using ammonium persulphate as an initiator. The graft copolymers (NaAlg-g-PVNCL) were characterized with Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy. Polymeric hydrogel beads of NaAlg and NaAlg-g-PVNC were prepared by crosslinking method using glutaraldehyde (GA) as a crosslinker in the hydrochloric acid catalyst (HCl) and these beads were used to deliver anti-cancer drug, 5-FU. In vitro release studies were performed in simulated intestinal fluid (pH 7.4) at different temperatures 25oc, 37oc for 12h. |
| 저자 |
스와미, 정일두
|
| 소속 |
부산대 |
| 키워드 |
sodium alginate; drug dlivery; in vitro release; 5-FU
|
| E-Mail |
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